李 虎^1，2，冯疆涛²，荣晓夙²，付海梅¹，冶雪婷¹，侯旭杰^1.3*

（1.塔里木大学生命科学学院，阿拉尔 843300；

2.阿克苏地区疾病预防控制中心，阿克苏 843000；

3.南疆特色农产品深加工兵团重点实验室，阿拉尔 843300）

摘 要：该实验将SPF级昆明种雄性小鼠（n=70）随机分为7组，每组10只，皮下注射D-半乳糖〔200mg/（kg·bw）〕建立衰老模型，同时给予不同剂量的慕萨莱思葡萄酒灌胃，6周后分别测定小鼠血清和肝脏、脑、心脏、肾脏组织中的超氧化物歧化酶（SOD）、过氧化物酶（GSH-Px）、过氧化氢酶（CAT）的活性及丙二醛（MDA）含量。检测结果显示，慕萨莱思葡萄酒可以显著增加小鼠血清和肝脏、心脏、肾脏组织中的SOD、GSH-Px、CAT的活性以及脑组织中SOD、GSH-Px的活性，降低MDA含量。结果表明慕萨莱思葡萄酒具有良好的体内抗氧化作用。

关键词：慕萨莱思；抗氧化；超氧化物歧化酶；过氧化物酶；丙二醛；过氧化氢酶

中图分类号：TS262.6  文献标识码：A  文章编号：1674-506X（2026）01-0072-0006

Antioxidant Effects of Musalles Wine on D-galactose Induced Aging Mice

LI Hu^1，2，FENG Jiangtao²，RONG Xiaosu²，FU Haimei¹，YE Xueting¹，HOU Xujie^1，3*

（1.College of Life Science，Tarim University，Alar 843300，China；

2.Regional Center for Disease Prevention and Control，Aksu 843000，China；

3.Construction Corps Key Laboratory of Special Agricultural Products Further Processing in Southern Xinjiang，Alar 843300，China）

Abstract：In this experiment，Kunming male mice （SPF）（n=70） were randomly divided into 7 groups，with 10 in each group，hypodermic injection of D-galactose ［200 mg/（kg·bw）］ was used to establish an aging model， and different doses of Musalles wine were orally administered. After 6 weeks， the activities of superoxide dismutase （SOD），glutathione peroxidase （GSH-Px），catalase （CAT） activity，and malondialdehyde （MDA）content in mouse serum，liver，brain，heart，and kidney tissues were tested. The results showed that Musalles wine could significantly increase the activities of SOD，GSH-Px and CAT in the serum，liver，heart and kidney tissues，as well as the activities of SOD and GSH-Px in the brain tissues of mice，and decrease the MDA content. This experiment shows Musalles wine has good in vivo antioxidant effect.

Keywords：Musalles wine；antioxidant；SOD；GSH-Px；MDA；CAT

doi：10.3969/j.issn.1674-506X.2026.01-010